More and more often practitioners in process industry have to adapt their global production networks to changes in the competitive environment. A majority of the supply network design models proposed by academia does not sufficiently capture the economic and technical questions that have to be resolved. This work seeks to provide the necessary operations research decision support tools. It builds on the example of specialty chemicals industry, which faces a strong increase of competitive pressure and historically grown production networks that typically lack a coherent design strategy. Decision makers have to define a production network re-design strategy that allows them to capture the competitive advantages of a global production network. Therefore, the book proposes a planning process split into the two phases: global production network optimization and individual site selection. To support the former a comprehensive Mixed-Integer Linear Programming model is proposed while an approach based on the Analytic Hierarchy Process is suggested for the latter. Findings from a case study demonstrate the applicability of the tools presented to real-world production networks and the insights the use of OR methods can provide in practice.